Eva Bittrich

Design of new responsive materials based on functional polymer brushes

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Kurzfassung in Englisch

For the development of smart surfaces high attention is focused on stimuli-responsive polymers. Since type and rate of response to environmental stimuli can be regulated by chain length, composition, architecture and topology, polymer films offer a variety of opportunities to develop such stimuli-responsive surfaces. Here polymer brush surfaces designed for a controlled adsorption of proteins and a switchable activity of immobilized enzymes are presented. The work is focused on temperature as well as pH-sensitive binary brushes, consisting of poly(N-isopropylacrylamide) (PNIPAAm) and poly(acrylic acid) (PAA), and their swelling behavior as well as their protein adsorption affinity is compared to the corresponding homopolymer brushes. All polymer brushes are covalently grafted by ester bonds to an anchoring layer of poly(glycidyl methacrylate), that itself is grafted via ether bonds to a silicon surface.
Methodical investigations of layer thickness and refractive index of the brushes in the swollen state and after protein adsorption are carried out with in-situ spectroscopic ellipsometry, varying the brush composition and the solution parameters pH, salt concentration and temperature. The ellipsometric findings are correlated to results of contact angle, atomic force microscopy and zeta-potential measurements as well as colorimetric assays of enzyme activities at the brush surface. Furthermore the swelling of PNIPAAm brushes and protein adsorption at PAA Guiselin brushes are investigated in more detail with attenuated total reflexion Fourier-transform infrared spectroscopy and quartz crystal microbalance with dissipation, respectively.

weitere Metadaten

Ellipsometrie, Polymerbürsten, Proteinadsorption, Quellung
ellipsometry, polymer brush, protein adsorption, swelling
DDC Klassifikation570
RVK KlassifikationWD 5100
HochschuleTechnische Universität Dresden
FakultätFakultät Mathematik und Naturwissenschaften
BetreuerProf. Manfred Stamm
GutachterProf. Manfred Stamm
Prof. Willem Norde
Tag d. Einreichung (bei der Fakultät)13.08.2010
Tag d. Verteidigung / Kolloquiums / Prüfung16.11.2010
Veröffentlichungsdatum (online)30.11.2010
persistente URNurn:nbn:de:bsz:14-qucosa-62669

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