Caroline Sievers, Jens Klotsche, Lars Pieper, Harald J. Schneider, Winfried März, Hans-Ulrich Wittchen, Günter K. Stalla, Christos Mantzoros

Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients

Dokumente und Dateien

Hinweis

Bitte nutzen Sie beim Zitieren immer folgende Url:

http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-100966

Kurzfassung in Englisch

Objective: Although associations between testosterone and cardiovascular (CV) morbidity in women have been proposed, no large prospective study has evaluated potential associations between testosterone and mortality in women. The objective was to determine whether baseline testosterone levels in women are associated with future overall or CV morbidity and mortality.

Design: Prospective cohort study with a 4.5-year follow-up period.

Methods: From a representative sample of German primary care practices, 2914 female patients between 18 and 75 years were analyzed for the main outcome measures: CV risk factors, CV diseases, and all-cause mortality.

Results: At baseline, the study population was aged 57.96±14.37 years with a mean body mass index of 26.71±5.17 kg/m2. No predictive value of total testosterone for incident CV risk factors or CV diseases was observed in logistic regressions. Patients with total testosterone levels in the lowest quintile Q1, however, had a higher risk to die of any cause or to develop a CV event within the follow-up period compared to patients in the collapsed quintiles Q2–Q5 in crude and adjusted Cox regression models (all-cause mortality: Q2–Q5 versus Q1: crude hazard ratios (HR) 0.49, 95% confidence interval (CI) 0.33–0.74; adjusted HR 0.62, 95% CI 0.42–0.939; CV events: Q2–Q5 versus Q1: crude HR 0.54, 95% CI 0.38–0.77; adjusted HR 0.68, 95% CI 0.48–0.97). Kaplan–Meier curves revealed similar data.

Conclusions: Low baseline testosterone in women is associated with increased all-cause mortality and incident CV events independent of traditional risk factors.

weitere Metadaten

Schlagwörter
(Deutsch)
Testosteron, Herz-Kreislauferkrankung, Mortalität, Kohorten-Studie
Schlagwörter
(Englisch)
testosterone, cardiovascular disease, mortality, cohort study
DDC Klassifikation610
RVK KlassifikationYM 3120
Institution(en) 
InstitutionBioScientifica
DokumententypArtikel
SpracheEnglisch
Erstveröffentlichungjahr der Druckausgabe2010
Veröffentlichungsdatum (online)01.02.2013
persistente URNurn:nbn:de:bsz:14-qucosa-100966
QuelleEuropean Journal of Endocrinology, Bd. 163 (2010), S. 699-708, ISSN: 0804-4643
DOI10.1530/EJE-10-0307
Externe Referenzhttp://dx.doi.org/10.1530/EJE-10-0307
Metadaten und Abstract zu dem Artikel, der zuerst in der Zeitschrift "European Journal of Endocrinology" des BioScientifica-Verlages veröffentlicht wurde.

Hinweis zum Urheberrecht

Diese Website ist eine Installation von Qucosa - Quality Content of Saxony!
Sächsische Landesbibliothek Staats- und Universitätsbibliothek Dresden